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News From Around the System

Key Decision Point for Brain Development Identified

UCSF Health — February 18, 2021

In a new study, UCSF and Stanford researchers have identified a central switch that appears to control when neural progenitor cells stop multiplying and start differentiating into mature neurons.

First-in-Human Clinical Trial to Assess Gene Therapy for Alzheimer’s Disease

UC San Diego Health — February 18, 2021

UC San Diego researchers have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer’s disease or Mild Cognitive Impairment, a condition that often precedes full-blown dementia.

Genetics May Play Role in Determining Immunity to COVID-19

UC San Diego Health — February 18, 2021

UC San Diego researchers report that individual immune response to SARS-CoV-2 may be limited by a set of variable genes that code for cell surface proteins essential for the adaptive immune system. The finding may help explain why COVID-19 immunity varies by individual.

Chatter Between Cell Populations Drives Progression of Gastrointestinal Tumors

UC San Diego Health — February 18, 2021

Gastrointestinal stromal tumors (GISTs) are a subtype of cancers known as sarcomas. GIST is the most common type of sarcoma with approximately 5,000 to 6,000 new patient cases annually in the United States. GIST cannot be cured by drugs alone, and targeted therapies are only modestly effective,...

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