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News From Around the System

Diet Plays Critical Role in NASH Progressing to Liver Cancer in Mouse Model

UC San Diego Health — May 12, 2022

Researchers at UC San Diego School of Medicine found in a mouse model that when fed a Western diet rich in calories, fat and cholesterol, the mice progressively became obese, diabetic and developed NASH, which progressed to HCC, chronic kidney and cardiovascular disease.

Despite COVID-19 Pandemic First Patient Undergoes New Personalized Immunotherapy

UC San Diego Health — May 12, 2022

Bernard Thurman was referred to a personalized cancer therapy trial at Moores Cancer Center at UC San Diego Health, a collaboration with the La Jolla Institute for Immunology, the trial employs a patient’s immune cells — specifically tumor infiltrating lymphocytes (TIL) — to destroy cancer cells.

Current Clinical Trial Assessing Potential of CBD in Treatment of Autism

UC San Diego Health — May 12, 2022

Researchers at University of California San Diego School of Medicine are recruiting eligible children between the ages of seven and fourteen years for a Phase III clinical trial to determine whether cannabidiol (CBD) reduces severe behavior problems in children with autism spectrum disorder.

COVID-19 Virus Uses Heparan Sulfate to Get Inside Cells

UC San Diego Health — May 12, 2022

UC San Diego researchers discovered that the SARS-CoV-2 virus can’t grab hold of cell receptor ACE2 without a carbohydrate called heparan sulfate, which is also found on lung cell surfaces — disrupting that interaction with a repurposed drug may help treat COVID-19.

Cross Border Effort to Vaccinate 10,000 Maquiladora Workers

UC San Diego Health — May 12, 2022

A coalition of six U.S. subsidiary companies have sponsored a COVID-19 mobile clinic to vaccinate 10,000 maquiladora workers employed in Baja California, Mexico. UC San Diego Health is vaccinating about 1,500 workers daily.

Common Class of Drugs Linked to Increased Risk of Alzheimer’s Disease

UC San Diego Health — May 12, 2022

UC San Diego researchers report that a class of drugs used for a broad array of conditions, from allergies and colds to hypertension and urinary incontinence, may be associated with an increased risk of cognitive decline, particularly in older adults at greater risk for Alzheimer’s disease.

Common Acid Reflux Medications Linked to Increased Kidney Disease Risk

UC San Diego Health — May 12, 2022

Mining a large database of adverse reactions to medications, UC San Diego researchers found that people who took proton pump inhibitors (e.g., Prilosec, Nexium) for heartburn and acid reflux were more likely to experience kidney disease than people who took other forms of antacid.

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