The grant is to study whether patients with renal stones can be treated as effectively with ultrasound as radiation-delivering CT scans.

Rebecca Smith-Bindman, UC San Francisco
As concerns mount about unregulated radiation dosages from CT scans, Rebecca Smith-Bindman’s study will examine if ultrasound is a viable alternative for patients with renal stones.
Smith-Bindman, MD, a professor of radiology at UCSF, recently received a $9.2 million comparative effectiveness award through the federal economic stimulus package known as the American Recovery and Reinvestment Act (ARRA).
The ARRA grant is to study whether emergency room patients with renal stones can be treated as effectively with ultrasound as radiation-delivering CT scans. The grant follows Smith-Bindman’s research published last December that found radiation doses from common CT procedures vary widely and are higher than generally thought, raising concerns about increased risk for cancer.
That research reviewed procedures performed on 1,119 patients at four San Francisco Bay Area institutions over five months and found a 13-fold variation between the highest and lowest radiation dose for each type of CT procedure.
“Dose awareness has increased profoundly in the last six months, and at UCSF, we’re really making a concerted effort to try and reduce the doses associated with a large number of CT scan types,” said Smith-Bindman. “That’s resulted in improved safety by lowering the dose for the same study type. “
The grant is among more than 45 awards UCSF has received through ARRA that have been targeted towards understanding of what works – and doesn’t – in real-life hospital and clinic practice settings. Known as comparative effectiveness research, the projects involve multiple medical centers throughout the nation, assessing actual clinical practice and patient outcomes in areas ranging from prenatal testing and children’s oral health to treating stroke and traumatic brain injuries.
The grants are particularly significant in the ongoing debate over health care reform, with the increasing scrutiny on both the cost of health care and the quality provided. In that context, comparative effectiveness research – or identifying the best practices among different health care models in preventing, diagnosing, treating, and monitoring disease — has been touted as one possible solution to rising health care costs.


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