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Prenatal pesticide exposure tied to lower IQ in children

UC Berkeley study is among a trio of new papers showing an association between pesticide exposure and childhood IQ.


uch_ucb_pesticides_tractorIn a new study suggesting pesticides may be associated with the health and development of children, researchers at UC Berkeley’s School of Public Health have found that prenatal exposure to organophosphate pesticides – widely used on food crops – is related to lower intelligence scores at age 7.

The researchers found that every 10-fold increase in measures of organophosphates detected during a mother’s pregnancy corresponded to a 5.5 point drop in overall IQ scores in the 7-year-olds. Children in the study with the highest levels of prenatal pesticide exposure scored seven points lower on a standardized measure of intelligence compared with children who had the lowest levels of exposure.

“These associations are substantial, especially when viewing this at a population-wide level,” said study principal investigator Brenda Eskenazi, UC Berkeley professor of epidemiology and of maternal and child health. “That difference could mean, on average, more kids being shifted into the lower end of the spectrum of learning, and more kids needing special services in school.”

The UC Berkeley study is among a trio of papers showing an association between pesticide exposure and childhood IQ to be published online April 21 in the journal Environmental Health Perspectives. Notably, the other two studies – one at Mt. Sinai Medical Center, the other at Columbia University – examined urban populations in New York City, while the UC Berkeley study focused on children living in Salinas, an agricultural center in Monterey County.

The studies in New York also examined prenatal exposure to pesticides and IQ in children at age 7. Like the UC Berkeley researchers, scientists at Mt. Sinai sampled pesticide metabolites in maternal urine, while researchers at Columbia looked at umbilical cord blood levels of a specific pesticide, chlorpyrifos.

“It is very unusual to see this much consistency across populations in studies, so that speaks to the significance of the findings,” said lead author Maryse Bouchard, who was working as a UC Berkeley postdoctoral researcher with Eskenazi while this study was underway. “The children are now at a stage where they are going to school, so it’s easier to get good, valid assessments of cognitive function.”

Organophosphates (OP) are a class of pesticides that are well-known neurotoxicants. Indoor use of chlorpyrifos and diazinon, two common OP pesticides, has been phased out over the past decade, primarily because of health risks to children.

The 329 children in the UC Berkeley study had been followed from before birth as part of the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), an ongoing longitudinal study led by Eskenazi. The new findings on IQ come less than a year after another study from the CHAMACOS cohort found an association between prenatal pesticide exposure and attention problems in children at age 5.

Researchers began enrolling pregnant women in the study in 1999. During pregnancy and after the children were born, study participants came to regular visits where CHAMACOS staff administered questionnaires and measured the health and development of the children.

During the visits, samples of urine were taken from the participants and tested for dialkyl phosphate (DAP) metabolites, the breakdown product of about 75 percent of the organophosphorus insecticides in use in the United States. Samples were taken twice during pregnancy, with the two results averaged, and after birth from the children at regular intervals between ages 6 months and 5 years.

The Wechsler Intelligence Scale for Children – Fourth Edition (WISC-IV) was used to assess the cognitive abilities of the children at age 7. The test includes subcategories for verbal comprehension, perceptual reasoning, working memory and processing speed.

In addition to the association with overall IQ scores, each of the four cognitive development subcategories saw significant decreases in scores associated with higher levels of DAPs when the mothers were pregnant. The findings held even after researchers considered such factors as maternal education, family income and exposure to other environmental contaminants, including DDT, lead and flame retardants.

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